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September 10, 2025Journal of dementia and Alzheimer's diseaseOpen Access

Microglial Neuroinflammation in Alzheimer’s Disease: Mechanisms and Therapies

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Authors

EEEmine ErdağIHIsmail Celil Haskologlu

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Overview

This review evaluates neuroinflammation and microglial roles in Alzheimer’s disease, suggesting immunomodulatory therapies.

Key Points

  • Microglial dysfunction contributes to neuroinflammation and neuronal loss in Alzheimer’s disease.
  • Recent findings indicate critical roles of TREM2 signaling and NLRP3 inflammasome in microglial activation.
  • The review synthesizes insights from experimental and clinical studies on microglial pathways and therapeutic strategies.
  • Targeting microglial dysfunction through various therapeutic approaches shows promise in modifying Alzheimer’s disease progression.

Cite This Study

Erdağ et al. (2025) studied this question.

synapsesocial.com/papers/68c24364b210217d647a6787https://doi.org/10.3390/jdad2030029
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Neuroinflammation and Alzheimer's disease: Unravelling the molecular mechanisms2025
  2. 2The Role of Microglial Cells and Cytokine Modulation in Alzheimer’sDisease: A Neuroinflammatory Perspective2026 · 3 citations
  3. 3Targeting glial dysfunction in Alzheimer’s disease: insights into pathogenesis and emerging therapeutics2025 · 4 citations
  4. 4Targeting Inflammation in Alzheimer’s Disease: Insights Into Pathophysiology and Therapeutic Avenues-A Comprehensive Review2025
  5. 5Microglia-Neuron Interactions in Alzheimer’s Disease2025