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July 26, 2026BMC Cardiovascular DisordersOpen Access

Association of the TyG-related indices with hypertension–diabetes comorbidity in middle-aged and older adults: a suburban community-based study

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Why the study?

Are TyG-related indices associated with hypertension-diabetes comorbidity in middle-aged and older adults?

Population

2,854 middle-aged and older adults (aged ≥ 45 years) living in a suburban community

Comparison

TyG-related indices (TyG, TyG-BMI, and TyG-BRI) vs Lowest quartile of TyG-related indices

Design

Cross-sectional

Key result

Each 1-SD increment in the TyG index was significantly associated with increased odds of hypertension-diabetes comorbidity (OR 3.16; 95% CI 2.75-3.64; P<0.001).

Authors

FKFanlian KongYYY YJZJin Zhao

Discussion

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Overview

TyG indices associate with hypertension-diabetes comorbidity; hypothesis-generating and should not yet change practice.

Key Points

  • This research aims to investigate the relationship between TyG-related indices and hypertension-diabetes comorbidity among middle-aged and older adults.
  • Included 2854 participants aged ≥ 45 years from a suburban community.
  • Utilized multivariable logistic regression to calculate odds ratios and confidence intervals.
  • Employed restricted cubic splines to assess dose-response relationships and ROC curves to evaluate discriminative performance.
  • 1-SD increment in TyG, TyG-BMI, and TyG-BRI resulted in adjusted ORs of 3.16 (95% CI 2.75–3.64), 1.39 (95% CI 1.15–1.66), and 1.37 (95% CI 1.22–1.54), respectively, all P < 0.001.
  • Highest quartile showed ORs of 30.99 (95% CI 16.97–62.97) for TyG, 6.42 (95% CI 4.20-10.14) for TyG-BMI, and 6.43 (95% CI 4.21–10.17) for TyG-BRI.
  • TyG showed the highest AUC of 0.786, indicating strong discriminative ability compared to TyG-BMI and TyG-BRI.

Study Design

Type

Cross-Sectional (n=2,854)

Structured PICO

Are TyG-related indices associated with hypertension-diabetes comorbidity in middle-aged and older adults?

P
Population
2,854 adults aged ≥ 45 years living in a suburban community evaluated for the association between TyG-related indices and hypertension-diabetes comorbidity.
E
Exposure
TyG-related indices (TyG, TyG-BMI, and TyG-BRI)
C
Comparator
Lowest quartile of TyG-related indices
O
Outcome
Hypertension-diabetes comorbidity (HTN-DM)

Main Result

Odds Ratio: 3.16 (95% CI 2.75–3.64)

p-value: p=<0.001

Cite This Study

Kong et al. (2026) conducted a cross-sectional in Hypertension-diabetes comorbidity (n=2,854). TyG-related indices (TyG, TyG-BMI, TyG-BRI) vs. Lower levels of TyG-related indices was evaluated on Hypertension-diabetes comorbidity (HTN-DM) (OR 3.16, 95% CI 2.75-3.64, p=<0.001). Each 1-SD increment in the TyG index was significantly associated with increased odds of hypertension-diabetes comorbidity (OR 3.16; 95% CI 2.75-3.64; P<0.001).

synapsesocial.com/papers/6a65aadfd3aea3239cd794c8https://doi.org/10.1186/s12872-026-06313-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1First Comparative Evaluation of TyG‐ABSI Versus Traditional TyG‐Related Indices for Cardiovascular Disease and Mortality Prediction in Hypertensive Patients2026
  2. 2Associations between novel triglyceride-glucose-related indices and the incidence of hypertension among Chinese middle-aged and elderly adults: a nationwide prospective cohort study2025
  3. 3Association between triglyceride-glucose index and its obesity indicators with hypertension in postmenopausal women: a cross-sectional study2025 · 1 citations
  4. 4TyG Index and Related Indices Predicting Hypertension: Mediation by Neutrophil-to-Lymphocyte Ratio in Multiple Chinese Cohorts2025
  5. 5Association of 14 triglyceride-glucose (TyG)-related indices with new-onset cardiovascular disease in middle-aged and older adults: evidence from the CHARLS and ELSA aging cohorts2026 · 1 citations