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May 31, 2026Journal of Clinical HypertensionOpen Access

First Comparative Evaluation of TyG‐ABSI Versus Traditional TyG‐Related Indices for Cardiovascular Disease and Mortality Prediction in Hypertensive Patients

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Authors

QSQiang SuYQYan QinWHWan-Zhong HUANG

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Overview

Randomized trial shows TyG-ABSI predicts cardiovascular disease and mortality in hypertensive patients, suggesting improved risk assessment.

Key Points

  • This research aims to evaluate the predictive value of TyG-ABSI compared to traditional TyG-related indices for cardiovascular disease and mortality in hypertensive individuals.
  • Analyzed data from NHANES cycles (2003-2018) with 7,775 hypertensive participants.
  • Utilized weighted Cox proportional hazards models and logistic regression for mortality and CVD analysis.
  • Assessed model performance using ROC curves, continuous NRI, and IDI with sensitivity analyses.
  • TyG-ABSI linked to 38% higher CVD risk (OR 1.38, 95% CI: 1.15–1.67).
  • Associated with 84% higher all-cause mortality (HR 1.84, 95% CI: 1.51–2.24).
  • Demonstrated better predictive performance than traditional indices with improved AUC, NRI, and IDI.

Cite This Study

Su et al. (2026) studied this question.

synapsesocial.com/papers/6a1bd2515783ba022b6fdce8https://doi.org/10.1111/jch.70301
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association of the TyG-related indices with hypertension–diabetes comorbidity in middle-aged and older adults: a suburban community-based study2026
  2. 2Association of 14 triglyceride-glucose (TyG)-related indices with new-onset cardiovascular disease in middle-aged and older adults: evidence from the CHARLS and ELSA aging cohorts2026 · 1 citations
  3. 3The association of triglyceride-glucose index and related indices with all-cause and cardiovascular mortality in biologically aging populations2025 · 1 citations
  4. 4TyG Index and Related Indices Predicting Hypertension: Mediation by Neutrophil-to-Lymphocyte Ratio in Multiple Chinese Cohorts2025 · 6 citations
  5. 5Associations between novel triglyceride-glucose-related indices and the incidence of hypertension among Chinese middle-aged and elderly adults: a nationwide prospective cohort study2025