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September 10, 2025NutrientsOpen Access

TyG Index and Related Indices Predicting Hypertension: Mediation by Neutrophil-to-Lymphocyte Ratio in Multiple Chinese Cohorts

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Authors

MSMengwen SunYHYuanyuan HuangXLXingqiang Lü

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Overview

Analysis from multiple Chinese cohorts shows TyG index predicts hypertension, implying NLR mediates associations.

Key Points

  • Elevated TyG index significantly predicts incident hypertension across cohorts, highlighting its role in cardiovascular health.
  • Each 1-unit increase in TyG corresponds to 9–36% greater odds of hypertension, emphasizing insulin resistance effects.
  • Mediation analysis shows neutrophil-to-lymphocyte ratio accounts for about 25% of TyG-hypertension relationship, underlining inflammation's impact.
  • Subgroup analyses indicate varied effects across age, sex, and residence, suggesting focused interventions may be necessary.

Cite This Study

Sun et al. (2025) studied this question.

synapsesocial.com/papers/68c23b08b210217d64783569https://doi.org/10.3390/nu17172859
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Also Consider

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  1. 1Association between triglyceride-glucose index and its obesity indicators with hypertension in postmenopausal women: a cross-sectional study2025 · 1 citations
  2. 2TyG Index in Predicting Arterial Hypertension in Normoglycemic Perimenopausal Women2025
  3. 3Associations between novel triglyceride-glucose-related indices and the incidence of hypertension among Chinese middle-aged and elderly adults: a nationwide prospective cohort study2025
  4. 4Association of the TyG-related indices with hypertension–diabetes comorbidity in middle-aged and older adults: a suburban community-based study2026
  5. 5Triglyceride-glucose index, HOmeostatic Model Assessment index, and new-onset hypertension in middle-aged men2025