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July 26, 2026Scientific ReportsOpen Access

Elevated TyG index linked to ~70% higher all-cause and cardiac mortality in PCI patients.

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Why the study?

Does an elevated triglyceride-glucose (TyG) index predict all-cause and cardiac mortality in patients with coronary heart disease undergoing PCI?

Population

2,533 patients with coronary heart disease who underwent percutaneous coronary intervention, using data from…

Comparison

Elevated triglyceride-glucose (TyG) index vs Lower triglyceride-glucose (TyG) index

Design

Cohort

Key result

An elevated Triglyceride-glucose (TyG) index was independently associated with an increased risk of all-cause mortality (OR 1.7) and cardiac mortality in patients with coronary heart disease undergoing percutaneous coronary intervention.

Authors

XWXin WanYSY ShiRZRuigui Zheng

Discussion

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Overview

TyG index may aid post-PCI mortality risk stratification; leaves open need for prospective validation before clinical adoption.

Key Points

  • The study aims to investigate the association between the triglyceride-glucose index and mortality risk in patients with coronary heart disease following percutaneous coronary intervention.
  • Analyzed data from 2,533 coronary heart disease patients who underwent PCI using the Dryad database
  • Conducted smooth curve analysis to assess correlation between TyG levels and mortality
  • Performed ROC analysis to evaluate predictive value of the TyG index combined with other factors
  • 120 (7.2%) patients died from any cause, with 80 (4.8%) attributed to cardiac causes
  • Higher TyG levels were independently associated with increased risk of all-cause mortality (OR 1.7, 95% CI 1.1–2.7) and cardiac mortality (OR 1.7, 95% CI 1.0–3.0)
  • ROC analysis indicated a predictive value for all-cause (AUC = 0.718) and cardiac mortality (AUC = 0.697) by combining TyG with age, sex, and smoking

Study Design

Type

Cohort (n=2,533)

Multicenter

No

Structured PICO

Does an elevated triglyceride-glucose (TyG) index predict all-cause and cardiac mortality in patients with coronary heart disease undergoing PCI?

P
Population
2,533 patients with coronary heart disease who underwent percutaneous coronary intervention with drug-eluting stents, followed for a median of 29.8 months.
E
Exposure
Elevated triglyceride-glucose (TyG) index
C
Comparator
Lower triglyceride-glucose (TyG) index
O
Outcome
All-cause and cardiac mortalityhard clinical

Main Result

Odds Ratio: 1.7 (95% CI 1.1–2.7)

p-value: p=0.030

An elevated triglyceride-glucose index is independently associated with an increased risk of all-cause and cardiac mortality in patients with coronary heart disease following PCI.

Limitations

  • Retrospective, single-center study design limits causal inference
  • TyG index was calculated only once at admission, so fluctuations during follow-up were unknown
  • No adjustments were made for lipid-lowering and hypoglycemic drugs
  • Exact causes of cardiac death were unclear
  • TyG index alone had poor discriminative performance (low AUC) as a standalone predictor
  • Missing clinical parameters such as left ventricular function and detailed angiographic severity due to retrospective design

Cite This Study

Wan et al. (2026) conducted a cohort in Coronary heart disease (CHD) following percutaneous coronary intervention (PCI) (n=2,533). Elevated Triglyceride-glucose (TyG) index vs. Lower Triglyceride-glucose (TyG) index was evaluated on All-cause death (OR 1.7, 95% CI 1.1-2.7, p=0.030). An elevated Triglyceride-glucose (TyG) index was independently associated with an increased risk of all-cause mortality (OR 1.7) and cardiac mortality in patients with coronary heart disease undergoing percutaneous coronary intervention.

synapsesocial.com/papers/6a65a36cd3aea3239cd76815https://doi.org/10.1038/s41598-026-62517-z
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Triglyceride glucose index in patients with acute coronary syndrome undergoing percutaneous coronary intervention predicts cardiovascular events: a cohort study2025 · 5 citations
  2. 2Triglyceride-glucose index as a novel prognostic biomarker for coronary artery disease: evidence from a large-scale prospective cohort study2025 · 6 citations
  3. 3The association between triglyceride-glucose index and all-cause/cardiovascular mortality in patients with different glucose metabolism statuses2025 · 11 citations
  4. 4Correlation of the triglyceride-glucose index with major adverse cardiovascular events in type 2 diabetes mellitus patients with acute myocardial infarction combined with HFpEF2025 · 2 citations
  5. 5Association Between Triglyceride-Glucose Index and Prognosis of Patients with Hypertrophic Cardiomyopathy and Heart Failure with Preserved Ejection Fraction2025