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September 26, 2025Cardiovascular DiabetologyOpen Access

The association between triglyceride-glucose index and all-cause/cardiovascular mortality in patients with different glucose metabolism statuses

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Authors

JLJiajun LiuJKJinhua KangPLPengpeng Liang

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Overview

This analysis reports TyG's impact on cardiovascular mortality in diabetes, indicating significant implications for diabetic care.

Key Points

  • An increase in triglyceride-glucose index correlated with a 35% higher risk of all-cause mortality in the normoglycemic group.
  • Cox regression results indicated a nonlinear association between TyG and mortality in diabetes, with an inflection point at 9.1.
  • Subgroup analyses revealed significant age and sex interactions affecting TyG's predictive performance on mortality outcomes.
  • Overall, TyG proved more predictive than the atherogenic index of plasma for 3-year mortality in both normoglycemic and diabetic individuals.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68d6964fcefa3de5aa871466https://doi.org/10.1186/s12933-025-02826-1
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