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July 19, 2026Blood Cancer JournalOpen Access

Temporal trends and demographic patterns in multiple myeloma incidence in the United States: a 24-year analysis of the CDC WONDER database (1999–2022)

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Authors

SMSidharth MahajanVOVaibhav Singh OberoiBMBenjamin Massat

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Overview

Retrospective analysis explores incidence of multiple myeloma in demographic groups, highlighting disparities.

Key Points

  • This analysis aims to evaluate the trends and disparities in multiple myeloma incidence across different demographic groups in the U.S.
  • Retrospective population-based analysis using CDC WONDER database from 1999 to 2022
  • Annual crude and age-adjusted incidence rates analyzed overall and by demographics
  • Joinpoint regression assessed temporal trends with annual percent change.
  • Age-adjusted incidence of multiple myeloma increased by approximately 23% from 1999 to 2022
  • Higher incidence in males (APC: 1.19%) and Black or African American individuals (APC: 1.40%) compared to White individuals (APC: 1.07%)
  • Incidence peaks at ages 80-84, with significant decline in those aged ≥85.

Cite This Study

Mahajan et al. (2026) studied this question.

synapsesocial.com/papers/6a5c6aa1118b92953e3ee95bhttps://doi.org/10.1038/s41408-026-01577-w
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Trends in mortality from multiple myeloma in patients younger than 55 years of age in the United States: A retrospective analysis from 1999 to 20202025
  2. 2Rising mortality trends in elderly multiple myeloma patients with hypertension: A CDC wonder database analysis (1999–2023)2025
  3. 3Long-term projections of multiple myeloma mortality in the United States(2024-2040).: A time-series analysis stratified by sex, race, and geography2025
  4. 4Trends and disparities in mortality due to coexisting respiratory infections and multiple myeloma among middle-aged and older adults in the United States.2026
  5. 5National trends in sepsis-specific mortality among adults in the United States with multiple myeloma, a 24-year analysis2025