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December 8, 2025BloodOpen Access

National trends in sepsis-specific mortality among adults in the United States with multiple myeloma, a 24-year analysis

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LKLove Kumar

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Overview

Analysis reveals declining sepsis mortality rates in adults with multiple myeloma since 1999, indicating ongoing disparities by age and location.

Key Points

  • To evaluate trends in sepsis-specific mortality among adults with multiple myeloma in the United States from 1999 to 2023.
  • Analyzed CDC WONDER data for sepsis-related deaths in adults with multiple myeloma
  • Calculated age-adjusted mortality rates and annual percent changes
  • Conducted Joinpoint regression for temporal trend analysis
  • Stratified analyses by age, sex, and geographic region
  • 29,612 sepsis-related deaths recorded from 1999 to 2023
  • Overall age-adjusted mortality rates declined from 0.68 to 0.55 per 100,000
  • Mortality rates for females declined steadily, while males showed variable trends
  • Significant regional mortality differences observed, with urban areas experiencing greater declines

Cite This Study

Love Kumar (2025) studied this question.

synapsesocial.com/papers/693624d44fa91c937236d057https://doi.org/10.1182/blood-2025-8130
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Trends and disparities in mortality due to coexisting respiratory infections and multiple myeloma among middle-aged and older adults in the United States.2026
  2. 2Trends and disparities in hematologic malignancy and sepsis-related mortality in adults aged ≥ 65 years in the United States from 1999 to2023: A CDC wonder database analysis2025
  3. 3Acute Myeloid Leukemia and sepsis-related mortality in the United States (U.S.) older adults: Nationwide trends and disparities over 25 years (1999 – 2023)2025
  4. 4Rising mortality trends in elderly multiple myeloma patients with hypertension: A CDC wonder database analysis (1999–2023)2025
  5. 5Trends in mortality from multiple myeloma in patients younger than 55 years of age in the United States: A retrospective analysis from 1999 to 20202025