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December 8, 2025BloodOpen Access

Trends in mortality from multiple myeloma in patients younger than 55 years of age in the United States: A retrospective analysis from 1999 to 2020

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Authors

FTFawad TalatRIRehan Ishaque

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Overview

Retrospective analysis reveals decreasing mortality trends in younger patients with multiple myeloma, indicating effective chemotherapy and immunotherapy strategies.

Key Points

  • To analyze mortality trends in patients younger than 55 with multiple myeloma from 1999 to 2020.
  • Retrospective analysis using CDC WONDER database
  • Identification of deaths from multiple myeloma via ICD-10 codes
  • Age-adjusted mortality rates calculated and analyzed by age, gender, and race.
  • Total of 16,706 deaths from multiple myeloma in younger patients during the study period
  • AAMR decreased for both genders, with males reporting higher rates than females
  • Black or African American individuals had the highest AAMR, significantly exceeding that of Whites.

Cite This Study

Talat et al. (2025) studied this question.

synapsesocial.com/papers/693624d44fa91c937236cfd0https://doi.org/10.1182/blood-2025-8141
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Long-term projections of multiple myeloma mortality in the United States(2024-2040).: A time-series analysis stratified by sex, race, and geography2025
  2. 2Temporal trends and demographic patterns in multiple myeloma incidence in the United States: a 24-year analysis of the CDC WONDER database (1999–2022)2026
  3. 3Trends in mortality from multiple myeloma and diabetes mellitus in the United States: A retrospective analysis from 1999 to 20202025
  4. 4Trends and disparities in mortality due to coexisting respiratory infections and multiple myeloma among middle-aged and older adults in the United States.2026
  5. 5Rising mortality trends in elderly multiple myeloma patients with hypertension: A CDC wonder database analysis (1999–2023)2025