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July 19, 2026Genes & DevelopmentOpen Access

Metabolic adaptations of the tumor macroenvironment and their role in cancer progression and survivorship

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Authors

DRDevesh RaizadaAGAna P. Gomes

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Overview

Review synthesizes evidence on tumor macroenvironment's metabolic changes impacting cancer progression and survivorship.

Key Points

  • This review aims to explore how metabolic changes in the tumor macroenvironment influence cancer progression and the long-term health of survivors.
  • Synthesis of emerging evidence from diverse studies on metabolic adaptations in cancer.
  • Analysis of tumor-host interactions and their systemic effects on metabolism.
  • Review of mechanisms relating to glucose, lipid, and protein metabolism, as well as immune system perturbations.
  • Cancer-induced metabolic changes promote tumor growth and metastasis.
  • Altered metabolism affects immune system function, leading to immune evasion.
  • Long-term health impacts include accelerated aging and therapy resistance in cancer survivors.

Cite This Study

Raizada et al. (2026) studied this question.

synapsesocial.com/papers/6a5c6a40118b92953e3ee5d3https://doi.org/10.1101/gad.353830.126
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Metabolic Adaptations in Cancer Progression: Optimization Strategies and Therapeutic Targets2025
  2. 2Metabolic adaptations in cancer progression2025
  3. 3Decoding the metabolic dialogue in the tumor microenvironment: from immune suppression to precision cancer therapies2025 · 32 citations
  4. 4Metabolic–immune nexus in tumor microenvironment: From mechanistic insights to therapeutic opportunities2025 · 11 citations
  5. 5Molecular Mediators of Metabolic Reprogramming in Cancer: Mechanisms, Regulatory Networks, and Therapeutic Strategies2025