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July 18, 2026Journal of Radiation Research and Applied SciencesOpen Access

THBS1-mediated macrophage polarization in the pathogenesis of sepsis-induced acute kidney injury

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Authors

YYYiqiong YangRLRumeng LiuYWYi Wang

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Overview

Randomized trial examines THBS1's impact on macrophage polarization and acute kidney injury, suggesting new treatment avenues.

Key Points

  • This investigation aims to explore the role of THBS1 in macrophage polarization during sepsis-related acute kidney injury.
  • RNA sequencing was used to profile gene expression in patients with sepsis-associated acute kidney injury.
  • A murine sepsis model was created, with THBS1 gene expression suppressed using siRNA technology.
  • In vitro studies involved LPS polarizing primary macrophages and co-culturing them with renal tubular cells.
  • THBS1 expression increased significantly in both human and murine sepsis cases, promoting M1 macrophage polarization.
  • Inhibition of THBS1 resulted in decreased oxidative stress and renal injury while promoting M2 macrophage differentiation.
  • Downregulation of THBS1 improved macrophage mitochondrial performance by correcting metabolic abnormalities.

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/6a5b181c18557b26c203a038https://doi.org/10.1016/j.jrras.2026.102573
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