September 10, 2025Mediators of InflammationOpen Access

HBP21 Alleviates Sepsis‐Induced Acute Kidney Injury by Targeting PI3K/AKT‐Mediated M1 Macrophage Polarization

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Discussion

Experimental analysis reveals HBP21 enhances M2 macrophage polarization in sepsis models, indicating therapeutic potential.

HBP21 overexpression reduces acute kidney injury by promoting M2 macrophage polarization and activating the PI3K/AKT pathway.
In vitro studies showed a 62.32% increase in cell viability and a 56.11% decrease in apoptosis with HBP21 treatment.
Animal models demonstrated that HBP21 expression significantly reduced serum creatinine by 38.5% and blood urea nitrogen by 47.4%.
Results indicate HBP21's potential as a therapeutic target for renal injuries associated with sepsis-induced acute kidney injury.

An et al. (2025) studied this question.

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September 10, 2025Mediators of InflammationOpen Access

View Full Paper

Ask AI

Bookmark

Authors

Experimental analysis reveals HBP21 enhances M2 macrophage polarization in sepsis models, indicating therapeutic potential.

HBP21 overexpression reduces acute kidney injury by promoting M2 macrophage polarization and activating the PI3K/AKT pathway.
In vitro studies showed a 62.32% increase in cell viability and a 56.11% decrease in apoptosis with HBP21 treatment.
Animal models demonstrated that HBP21 expression significantly reduced serum creatinine by 38.5% and blood urea nitrogen by 47.4%.
Results indicate HBP21's potential as a therapeutic target for renal injuries associated with sepsis-induced acute kidney injury.

An et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark