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July 11, 2026HereditasOpen Access

Upregulated miR-146b-5p is linked to AMI and predicts poor prognosis.

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Population

103 acute myocardial infarction patients and 95 healthy controls; in vitro ox-LDL-induced human coronary…

Comparison

Assessment of miR-146b-5p expression levels… vs Healthy controls; ox-LDL without inhibition

Design

Case-control

Key result

Upregulated miR-146b-5p expression was observed in 103 AMI patients compared to 95 healthy controls, demonstrating diagnostic value and predicting poor prognosis.

Authors

HWHailiang WuHZHui ZhangYHYuyan Hou

Discussion

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Overview

May aid AMI diagnosis if replicated; first human data extends miR-146b-5p observations to acute coronary syndromes.

Key Points

  • This study aims to investigate the role of miR-146b-5p in acute myocardial infarction and its implications for endothelial injury.
  • Analyzed serum from 103 AMI patients and 95 healthy controls using qRT-PCR for miR-146b-5p/PRKAR2A expression.
  • Conducted ROC curve analyses to evaluate diagnostic performance and correlation analyses with clinical markers.
  • Utilized in vitro models of ox-LDL-induced HCAEC injury with various assays to explore cellular mechanisms.
  • Upregulated miR-146b-5p in AMI patients correlated with hs-CRP, CK-MB, cTnI, LVEF, and Killip grade.
  • Higher miR-146b-5p was associated with a poor prognosis in AMI patients.
  • Inhibition of miR-146b-5p reduced apoptosis and inflammatory markers in ox-LDL-induced HCAECs, enhancing cell proliferation.

Study Design

Type

Case-Control (n=198)

Structured PICO

P
Population
198 participants, including 103 patients with acute myocardial infarction and 95 healthy controls, assessed for miR-146b-5p expression.
E
Exposure
Assessment of miR-146b-5p expression levels (clinical); miR-146b-5p inhibition (in vitro)
C
Comparator
Healthy controls (clinical); ox-LDL without inhibition (in vitro)
O
Outcome
Diagnostic performance, prognostic association, and cellular mechanisms of endothelial injury (apoptosis, inflammation, endothelial dysfunction)surrogate

miR-146b-5p is upregulated in AMI, correlates with disease severity and poor prognosis, and promotes endothelial injury by targeting PRKAR2A, suggesting it as a potential biomarker and therapeutic target.

Cite This Study

Wu et al. (2026) conducted a case-control in Acute myocardial infarction (n=198). miR-146b-5p expression vs. Healthy controls was evaluated on Diagnosis and prognosis of acute myocardial infarction. Upregulated miR-146b-5p expression was observed in 103 AMI patients compared to 95 healthy controls, demonstrating diagnostic value and predicting poor prognosis.

synapsesocial.com/papers/6a51deadc18d7f28ca5005f2https://doi.org/10.1186/s41065-026-00706-6
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