Cellular analysis shows circ_0091761 regulates miR-1278 in endothelial injury due to acute myocardial infarction, suggesting a potential therapeutic target.
Key Points
Suppressing circ_0091761 reduces endothelial injury in acute myocardial infarction, improving health outcomes.
Inhibition of circ_0091761 led to decreased levels of apoptosis and inflammatory markers such as ICAM1 and VCAM1.
Cellular models demonstrated that circ_0091761 interacts negatively with miR-1278, influencing endothelial cell response.
Results suggest targeting circ_0091761 may provide novel therapeutic strategies for managing myocardial infarction injuries.