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August 14, 2025

Macrophage Derived Galectin-3 Promotes Renal Fibrosis and Diabetic Kidney Disease by Enhancing TGFβ1 Signaling.

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Authors

YCYibing ChenQJQian JiangXXXiaowei Xing

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Overview

Observational analysis highlights galectin-3's role in promoting renal fibrosis in diabetic kidney disease, suggesting it as a potential target for therapy.

Key Points

  • Galectin-3 promotes renal fibrosis in diabetic kidney disease, indicating its significance in chronic kidney conditions.
  • In diabetic mice, Galectin-3 levels correlated with renal fibrosis, highlighting potential biomarkers for disease progression.
  • Analysis involved macrophage-derived Galectin-3 and its mechanisms in enhancing TGFβ1 signaling to promote fibrosis.
  • Targeting galectin-3 may enable therapeutic strategies to combat diabetic kidney disease and related fibrosis.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/689fc962e46e096235ce1d13https://doi.org/10.1002/advs.202504032
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Also Consider

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  1. 1The Role of Galectin-3 as a Biomarker in the Cardio-Renal-Metabolic Pathology Axis.2025
  2. 2Galectin-3/CD146 interaction promotes renal damage and systemic inflammation after acute kidney injury2025
  3. 3Galectin‐3 and kidney function in type 2 diabetes treated with dapagliflozin: Analysis from DECLARE‐TIMI 582025
  4. 4Assessment of Galectin-3 with Biochemical Changes in Patients with Chronic Kidney Disease2025
  5. 5NGAL drives cardiac dysfunction and fibrosis in rats with chronic kidney disease2025