What question did this study set out to answer?

To compare the hemodynamic response of resistance training on the leg press based on muscle mass used in patients with chronic heart failure.

July 3, 2026Open Access

Two-leg press training elicits higher HR, BP, and cardiac output versus one-leg in men with CHF.

Q: What is the clinical evidence from this study?

Study design: RCT. Population: Chronic heart failure (n=23). Intervention: Dynamic resistive training on the leg press with both legs vs. Dynamic resistive training on the leg press with one leg. Primary outcome: Hemodynamic response (heart rate, blood pressure, and cardiac output).

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Why the study?

Does two-leg resistive training compared to one-leg resistive training alter the acute hemodynamic response in men with chronic heart failure?

Population

23 men with left ventricular dysfunction after a myocardial infarction or coronary artery bypass graft…

Comparison

Dynamic resistive training exercise of high… vs The same dynamic resistive training exercise…

Design

RCT, The order of the one-leg and two-leg exercises was randomized.

Follow-up

Acute (during exercise)

Key result

Dynamic resistive training on the leg press with both legs elicited significantly higher heart rate, blood pressure, and cardiac output compared to one leg in men with chronic heart failure.

Authors

AGAlexis Gillet MLMichel Lamotte PBPhilippe van de Borne

Discussion

Member takes

Overview

Two-leg leg press increases acute hemodynamic load versus one-leg in HF; extends evidence guiding resistance exercise prescription in cardiac rehab.

Key Points

To compare the hemodynamic response of resistance training on the leg press based on muscle mass used in patients with chronic heart failure.
Twenty-three men with left ventricular dysfunction participated in high-intensity resistance training.
Performed leg press exercises using one leg and two legs, with randomization in order.
Monitored heart rate, blood pressure, and stroke volume continuously using a noninvasive measurement system.
Higher heart rate parameters, blood pressure, and cardiac output were observed during two-leg exercises compared to one-leg exercises.
No significant difference in peripheral vascular resistance was noted between the two methods.
Increased cardiac output and systolic blood pressure were recorded during the third set of exercises.

Study Design

Type

RCT (n=23)

Randomization

Randomized

Multicenter

Structured PICO

Does two-leg resistive training compared to one-leg resistive training alter the acute hemodynamic response in men with chronic heart failure?

Population

23 men (mean age 61) with chronic heart failure and left ventricular dysfunction post-MI or CABG undergoing acute resistive training.

Intervention

Dynamic resistive training exercise of high intensity (75% 1 Maximum Voluntary Contraction) on the leg press, fast execution, 3 sets of 10 repetitions with one minute of recovery, performed on two legs.

Comparator

The same dynamic resistive training exercise performed on one leg.

Outcome

Hemodynamic impact including heart rate, blood pressure, stroke volume, and cardiac output during exercise.surrogate

High-intensity resistance training using both legs increases cardiac output and systolic blood pressure more than single-leg exercise, but remains hemodynamically safe for patients with chronic heart failure.

Cite This Study

Gillet et al. (2026) conducted an RCT in Chronic heart failure (n=23). Dynamic resistive training on the leg press with both legs vs. Dynamic resistive training on the leg press with one leg was evaluated on Hemodynamic response (heart rate, blood pressure, and cardiac output). Dynamic resistive training on the leg press with both legs elicited significantly higher heart rate, blood pressure, and cardiac output compared to one leg in men with chronic heart failure.

synapsesocial.com/papers/6a4750705c29257aa2578243 https://doi.org/10.82161/hwh0-s057

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July 3, 2026Open Access

Two-leg press training elicits higher HR, BP, and cardiac output versus one-leg in men with CHF.

View Full Paper

Ask AI

Bookmark

Why the study?

Does two-leg resistive training compared to one-leg resistive training alter the acute hemodynamic response in men with chronic heart failure?

Population

23 men with left ventricular dysfunction after a myocardial infarction or coronary artery bypass graft…

Comparison

Dynamic resistive training exercise of high… vs The same dynamic resistive training exercise…

Design

RCT, The order of the one-leg and two-leg exercises was randomized.

Follow-up

Acute (during exercise)

Key result

Dynamic resistive training on the leg press with both legs elicited significantly higher heart rate, blood pressure, and cardiac output compared to one leg in men with chronic heart failure.

Authors

AGAlexis Gillet MLMichel Lamotte PBPhilippe van de Borne

Discussion

Member takes

Overview

Two-leg leg press increases acute hemodynamic load versus one-leg in HF; extends evidence guiding resistance exercise prescription in cardiac rehab.

Key Points

To compare the hemodynamic response of resistance training on the leg press based on muscle mass used in patients with chronic heart failure.
Twenty-three men with left ventricular dysfunction participated in high-intensity resistance training.
Performed leg press exercises using one leg and two legs, with randomization in order.
Monitored heart rate, blood pressure, and stroke volume continuously using a noninvasive measurement system.
Higher heart rate parameters, blood pressure, and cardiac output were observed during two-leg exercises compared to one-leg exercises.
No significant difference in peripheral vascular resistance was noted between the two methods.
Increased cardiac output and systolic blood pressure were recorded during the third set of exercises.

Study Design

Type

RCT (n=23)

Randomization

Randomized

Multicenter

Structured PICO

Does two-leg resistive training compared to one-leg resistive training alter the acute hemodynamic response in men with chronic heart failure?

Population

23 men (mean age 61) with chronic heart failure and left ventricular dysfunction post-MI or CABG undergoing acute resistive training.

Intervention

Comparator

The same dynamic resistive training exercise performed on one leg.

Outcome

Hemodynamic impact including heart rate, blood pressure, stroke volume, and cardiac output during exercise.surrogate

Cite This Study

synapsesocial.com/papers/6a4750705c29257aa2578243 https://doi.org/10.82161/hwh0-s057

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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