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June 12, 2026European Journal of Preventive CardiologyOpen Access

Systolic blood pressure was significantly higher during moderate load (15RM) compared with high load (4RM) across all sets (e.g., Set 3: 185±43 vs. 141±17 mmHg, p=0.002).

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Why the study?

Does high-load resistance exercise reduce acute hemodynamic responses compared to moderate-load resistance exercise in patients with chronic heart failure?

Population

13 patients with stable chronic heart failure due to reduced left ventricular ejection fraction, of which 10…

Comparison

High load resistance exercise consisting of… vs Moderate load resistance exercise consisting of…

Design

RCT, Randomized cross-over design

Follow-up

Acute (during and post-exercise)

Authors

BNB B N NilssonSOS OstbyeRWR Waarviken

Discussion

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Overview

May warrant load-specific BP monitoring during resistance exercise in stable CHF; leaves open optimal intensity guidelines pending larger trials.

Key Points

  • To investigate acute hemodynamic responses to different resistance exercise intensities in patients with chronic heart failure.
  • Conducted a randomized cross-over trial with 13 patients with stable CHF.
  • Participants performed seated knee-extensions with moderate (15RM) and high (4RM) loads across three sessions.
  • Monitored non-invasive hemodynamic responses and cardiac output at rest, during, and post-exercise.
  • Systolic blood pressure was significantly higher during moderate load compared to high load across all sets (S1: 162 vs 139 mmHg, p=0.023).
  • Diastolic blood pressure showed significant differences during S2 and S3 between moderate and high loads (S2: 109 vs 75 mmHg, p=0.002).
  • No significant differences in cardiac output were observed between the two loads.

Structured PICO

Does high-load resistance exercise reduce acute hemodynamic responses compared to moderate-load resistance exercise in patients with chronic heart failure?

P
Population
13 patients with stable chronic heart failure due to reduced left ventricular ejection fraction (LVEF < 40%), of which 10 completed the study (9 men, 1 woman, age 64 ± 7 years, LVEF 36 ± 6%).
I
Intervention
High load (4RM) resistance exercise consisting of three sets of seated knee-extensions.
C
Comparator
Moderate load (15RM) resistance exercise consisting of three sets of seated knee-extensions.
O
Outcome
Acute hemodynamic responses (systolic blood pressure, diastolic blood pressure, and cardiac output) measured at rest, during each set, and post-exercise.surrogate

High-load resistance exercise (4 repetitions) elicited significantly lower acute blood pressure responses than moderate-load exercise (15 repetitions) in patients with HFrEF, challenging current guideline recommendations.

Cite This Study

Nilsson et al. (2026) studied this question.

synapsesocial.com/papers/6a2bd1386550ea4541ffe9a3https://doi.org/10.1093/eurjpc/zwag249.048
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1ACUTE CARDIOVASCULAR RESPONSE TO RESISTANCE TRAINING DURING CARDIAC REHABILITATION: EFFECT OF MUSCLES MASS USED IN PATIENTS WITH CHRONIC HEART FAILURE2026
  2. 2Hemodynamic response to dynamic leg press resistance training in patients with coronary artery disease: preliminary data from hemodyret study2026
  3. 3Cardiovascular Responses to a Full Resistance Training Session Performed with and Without Blood Flow Restriction2025
  4. 4Comparative effects of different strength training modalities in cardiac rehabilitation: preliminary results2026
  5. 5Association between cardiac autonomic control and blood pressure response to resistance training in adults with pharmacologically treated hypertension2026