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June 12, 2026European Journal of Preventive CardiologyOpen Access

Systolic blood pressure was significantly higher during DLP-High compared to DLP-Low at Set 3 (190 [181-202] mmHg vs. 167 [157-174] mmHg, p < 0.05).

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Why the study?

Does high-intensity dynamic leg press resistance training induce different acute hemodynamic responses compared to low-intensity training in adults with coronary artery disease?

Population

12 adults with coronary artery disease (CAD), median age 68.5, 83% male.

Comparison

High-intensity dynamic leg press: three sets of… vs Low-intensity dynamic leg press: three sets of…

Design

RCT, Randomized crossover trial

Follow-up

Acute (during exercise and 30-minute washout)

Authors

FMF Mazzoli-RochaLRL RiemerCVC Vikoler

Discussion

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Overview

High-intensity leg press may provoke marked BP rises in CAD patients, warranting caution; leaves open optimal resistance training intensity.

Key Points

  • This research aims to compare the acute hemodynamic responses to different intensities of dynamic leg press resistance training in patients with coronary artery disease.
  • Prospective randomized crossover trial involving 12 adults with coronary artery disease.
  • Participants performed two dynamic leg press protocols: DLP-Low (40% 1RM) and DLP-High (80% 1RM).
  • Continuous non-invasive hemodynamic monitoring (SBP, DBP, pulse rate) was conducted during both training sessions.
  • Significant increase in SBP during both training protocols, higher in DLP-High (190 mmHg) compared to DLP-Low (167 mmHg) at Set 3 (p<0.05).
  • DBP increased significantly only during DLP-High, reaching 90 mmHg at Set 3 (p<0.001).
  • All participants tolerated the training well, with peak SBP values exceeding 220 mmHg in some cases, indicating considerable cardiovascular stress.

Structured PICO

Does high-intensity dynamic leg press resistance training induce different acute hemodynamic responses compared to low-intensity training in adults with coronary artery disease?

P
Population
12 adults with coronary artery disease (CAD), median age 68.5, 83% male.
I
Intervention
High-intensity dynamic leg press (DLP-High): three sets of 8 reps at 80% 1RM, executed at a fast speed (1.5 s concentric/eccentric) with 90-second rest between sets.
C
Comparator
Low-intensity dynamic leg press (DLP-Low): three sets of 15 reps at 40% 1RM, executed at a fast speed (1.5 s concentric/eccentric) with 90-second rest between sets (randomized crossover design).
O
Outcome
Acute hemodynamic responses (systolic blood pressure, diastolic blood pressure, pulse rate) measured continuously using a vascular unloading technique.surrogate

High-intensity dynamic leg press resistance training is well tolerated in CAD patients but induces marked, intensity-dependent elevations in systolic blood pressure compared to low-intensity training.

Cite This Study

Mazzoli-Rocha et al. (2026) studied this question.

synapsesocial.com/papers/6a2bd1386550ea4541ffe94fhttps://doi.org/10.1093/eurjpc/zwag249.342
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Acute hemodynamic responses during resistance exercise with different intensities in patients with chronic heart failure2026
  2. 2Hemodynamic response to isometric wall squat resistance training in patients with coronary artery disease: preliminary data from hemodyret study2026
  3. 3ACUTE CARDIOVASCULAR RESPONSE TO RESISTANCE TRAINING DURING CARDIAC REHABILITATION: EFFECT OF MUSCLES MASS USED IN PATIENTS WITH CHRONIC HEART FAILURE2026
  4. 4Cardiovascular Responses to a Full Resistance Training Session Performed with and Without Blood Flow Restriction2025
  5. 5Acute Blood Pressure Changes Following Resistance Exercise in Adults with Hypertension2025