Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 27, 2026Cancer MedicineOpen Access

A Prognostic Risk Model Based on Immune Genes in Thyroid Cancer and Its Correlation With Tumor‐Associated Immune Cell Infiltration Abundance

View Full Paper
Ask AI
Bookmark
Share

Authors

YZYufan ZhangSSShili SongXYXiaochen Yu

Discussion

Loading...

Member takes

Overview

Retrospective study investigates immune gene risk model in thyroid cancer, suggesting implications for patient prognosis.

Key Points

  • This research aims to develop a prognostic risk model for thyroid cancer based on immune gene expression and its relationship with immune cell infiltration.
  • Retrospective analysis of 117 thyroid cancer patients treated from May 2021 to December 2023.
  • COX regression model validated with ROC curves; immune cell subsets detected via flow cytometry.
  • External validation using TCGA thyroid cancer RNA-seq data (n = 512).
  • Lymph node metastasis (LNM), capsule invasion, and several immune genes are independent factors for poor prognosis (p < 0.05).
  • The prognostic model demonstrated an AUC of 0.925; significant variables included CDK1, B3GNT7, S100A9, and MMP12.
  • Correlation analysis revealed negative relationships between certain immune genes and B lymphocyte infiltration, while CD4+ and CD8+ T lymphocytes positively correlated with neutrophil and macrophage infiltration.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a3f6817aea7db3c1953f4cehttps://doi.org/10.1002/cam4.72037
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Multi-disease transcriptomic analysis of sex hormone genes reveals a novel prognostic model for thyroid cancer with breast cancer correlations2025
  2. 2The Prediction Model for Triple-Negative Breast Cancer Prognosis and Immunotherapy Efficacy Based on Single-Cell Sequencing of CD8+ T cells2025
  3. 3Identification of prognostic genes related to T cell proliferation in papillary thyroid cancer based on single-cell RNA sequencing and bulk RNA sequencing data2025 · 2 citations
  4. 4Identification of novel cholesterol metabolism-related biomarkers for thyroid cancer to predict the prognosis, immune infiltration, and drug sensitivity2025 · 2 citations
  5. 5Multi-omics analysis and metastasis risk factor prediction in N1b stage PTMC: insights into immune infiltration and therapeutic implications2025 · 3 citations