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September 10, 2025Clinical and Experimental MedicineOpen Access

Identification of prognostic genes related to T cell proliferation in papillary thyroid cancer based on single-cell RNA sequencing and bulk RNA sequencing data

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Authors

QMQingkai MengHLHsueh‐Erh LiuMWMengtong Wang

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Overview

Analysis links T cell proliferation genes to outcomes in papillary thyroid cancer, suggesting new treatment approaches.

Key Points

  • The identified prognostic genes KLRB1, TSHZ2, and TRABD2A provide insight into T cell proliferation in papillary thyroid cancer.
  • Cox regression and machine learning determined a risk model that effectively stratifies patients into high-risk and low-risk groups.
  • Single-cell RNA sequencing and bulk RNA sequencing revealed the immune microenvironment's role in patient prognosis.
  • Key interactions, such as CLEC2C-KLRB1, highlight critical communication between T/NK cells in the tumor environment.

Cite This Study

Meng et al. (2025) studied this question.

synapsesocial.com/papers/68c23fc3b210217d64797d97https://doi.org/10.1007/s10238-025-01826-5
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