Analysis reveals immune infiltration changes and metastasis risk factors in papillary thyroid microcarcinoma, highlighting therapeutic implications.
Key Points
Two clinical metastasis models were created, with Model A showing superior prediction accuracy (AUC = 0.852).
The neutrophil-to-lymphocyte ratio was identified as an independent risk factor for N1b-stage papillary thyroid microcarcinoma (OR = 2.12, p < 0.01).
Transcriptomic profiling uncovered a robust molecular signature linked to metastatic risk, with an AUC of 0.857 indicating strong predictive capability.
Comprehensive immune profiling indicated diminished CD8+ T cell infiltration, suggesting potential immune evasion in N1b-stage tumors.