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June 21, 2026Translational OncologyOpen Access

Single-cell and spatial transcriptomics reveal lactate-active epithelial–immune cell crosstalk that reprograms the immune microenvironment in colorectal cancer

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Authors

HLHaisheng LanYLYang LiHLHua Li

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Overview

Randomized trial reveals lactate metabolism's role in immune reprogramming in CRC, suggesting new therapeutic targets.

Key Points

  • This research investigates how lactate metabolism influences the immune microenvironment in colorectal cancer (CRC).
  • Integrated single-cell and spatial transcriptomics with bulk sequencing datasets.
  • Developed a lactate metabolism score (LMscore) based on four core genes: COX15, SLC25A13, COX10, MPC1.
  • Evaluated the relationship between LMscore, immune cell composition, and overall survival across cohorts.
  • High LMscore predicts decreased overall survival (HR range not specified) and associates with a 'cold' tumor immune phenotype.
  • Elevated LMscore indicates accumulation of immunosuppressive cells like M2 macrophages and CAFs, and fewer effector T-cells.
  • COX15 targeting suppresses tumor proliferation, indicating its role in lactate dysregulation.

Cite This Study

Lan et al. (2026) studied this question.

synapsesocial.com/papers/6a3781db24f042ddf4c5b733https://doi.org/10.1016/j.tranon.2026.102864
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A novel lactylation-related gene signature deciphers the immunosuppressive microenvironment and stratifies precision therapy in colorectal cancer2026
  2. 2Multi-omics analysis identifies lactylation-mediated immune biomarkers in esophageal cancer2025
  3. 3The integration of single-cell and metabolomics reveals the increase of oxidative phosphorylation during the liver metastasis of colorectal cancer2025
  4. 4Deciphering metabolic reprogramming of immune cells within the tumor microenvironment2025 · 10 citations
  5. 5Research Progress on Lactate-Mediated Tumor Metabolic Microenvironment-Driven Immunotherapy and Metabolic Reprogramming Strategies2025