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October 11, 2025Cancer & MetabolismOpen Access

The integration of single-cell and metabolomics reveals the increase of oxidative phosphorylation during the liver metastasis of colorectal cancer

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Authors

TLTianyu LiuSSSizheng SunYHYi‐Cheng Huang

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Overview

Analysis reveals elevated oxidative phosphorylation in colorectal cancer liver metastasis, implicating TGFβ signaling.

Key Points

  • Increased oxidative phosphorylation is identified as a key metabolic change during colorectal cancer liver metastasis.
  • Metabolomic profiling showed heightened tricarboxylic acid cycle activity linked to liver metastases.
  • Single-cell RNA sequencing demonstrated elevated OXPHOS in metastatic cells, implicating TGFβ pathway activation.
  • Inhibition of TGFβ signaling reduces oxidative phosphorylation and slows colorectal cancer liver metastasis progression.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68ea72339f1bd4df558cecd3https://doi.org/10.1186/s40170-025-00408-z
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