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June 20, 2026Current ProteomicsOpen Access

Integrated network pharmacology, behavior assessment, and bioinformatics to reveal the neuroprotective effect of Buzhong Yiqi Decoction combined with Fuzi Lizhong Decoction for diarrhea-predominant irritable bowel syndrome

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Authors

JZJing ZhaoMHMingli HanJJJiazan Jiang

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Overview

Randomized trial assesses BZFZ's neuroprotective effects in IBS-D, suggesting potential therapeutic implications.

Key Points

  • This study aims to investigate the effects of BZFZ on diarrhea-predominant irritable bowel syndrome (IBS-D) and uncover the underlying molecular mechanisms.
  • Identified active components and targets using network pharmacology, bioinformatics, and molecular docking.
  • Constructed an IBS-D rat model to evaluate BZFZ's in vivo effects.
  • Measured outcomes such as fecal output, abdominal withdrawal reflex, and inflammatory markers using ELISA and western blot.
  • Identified four key targets (MET, RAP1A, IRAK1, AGTR1) related to BZFZ's neuroprotective effects.
  • BZFZ significantly improved diarrhea and visceral sensitivity (all P < 0.05).
  • BZFZ treatment decreased IRAK1 levels and inhibited the MAPK signaling pathway (all P < 0.05).

Cite This Study

Zhao et al. (2026) studied this question.

synapsesocial.com/papers/6a3631cedb0793dc1a53883bhttps://doi.org/10.1016/j.curpro.2026.100118
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Decoding Barberry Root’s Therapeutic Network: A Synergistic Solution for IBS-D2025
  2. 2Multi-omics and machine learning uncover anti-IBS-C mechanism of Tiaoqi Daozhi decoction via immune-neuro-epithelial remodeling and VIP–PKA–AQP3 axis activation2026
  3. 3Deciphering the microbiological mechanism of Tongxie Yaofang in treating IBS-D: a multimodal mechanistic study in mice integrating network pharmacology, computational simulation, and 16S rRNA sequencing2025
  4. 4Exploring the Mechanism of Bu Zhong Yi Qi Decoction in Treating Sepsis-induced Acute Lung Injury based on Network Pharmacology and Experimental Verification2025
  5. 5Clinical Effect of Yin Yang Regulating Moxibustion on Diarrhea-predominant Irritable Bowel Syndrome2025