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October 2, 2025Current Pharmaceutical Design

Exploring the Mechanism of Bu Zhong Yi Qi Decoction in Treating Sepsis-induced Acute Lung Injury based on Network Pharmacology and Experimental Verification

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Authors

JLJiaxin LiJZJiayao ZhaoZSZack Shan

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Overview

Research explores the impact of Buzhong Yiqi Decoction on inflammation and oxidative stress in sepsis-induced acute lung injury.

Key Points

  • Buzhong Yiqi Decoction significantly reduces inflammatory factors and oxidative stress in sepsis-induced acute lung injury.
  • Molecular docking shows high binding activity of core components with key targets like TNF and AKT, indicating effective action.
  • Through network pharmacology, multiple databases identified relevant genes and pathways related to the treatment of sepsis-induced acute lung injury.
  • In vivo studies demonstrate Buzhong Yiqi Decoction's ability to decrease inflammation and improve lung tissue health in model mice.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68de68e583cbc991d0a21235https://doi.org/10.2174/0113816128397243250902131510
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Integrated network pharmacology, behavior assessment, and bioinformatics to reveal the neuroprotective effect of Buzhong Yiqi Decoction combined with Fuzi Lizhong Decoction for diarrhea-predominant irritable bowel syndrome2026
  2. 2Progress in Clinical and Basic Research of Buzhong Yiqi Decoction in Treating Lung Cancer2025
  3. 3The application of network pharmacology and molecular docking to investigate the mechanisms underlying the therapeutic effects of Salidroside in acute lung injury, along with validation through animal experiments2025
  4. 4Qifu Decoction Alleviates Lipopolysaccharide-Induced Myocardial Dysfunction by Inhibiting TLR4/NF-κB/NLRP3 Inflammatory Pathway and Activating PPARα/CPT Pathway2025
  5. 5Revealing the molecular mechanisms underlying Xuebijing against sepsis and septic acute kidney injury via bioinformatics and experimental approaches2025