Decoding Barberry Root’s Therapeutic Network: A Synergistic Solution for IBS-D

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Computational integration and in vitro experiments uncover Barberry Root's impact on IBS-D, highlighting inflammation and neurotransmission pathways.

Barberry Root showed potential in alleviating IBS-D symptoms through multi-pathway regulation.
Fifteen bioactive compounds and 85 overlapping targets were identified, with strong binding affinities in molecular docking.
In vitro and in vivo experiments confirmed Barberry Root's role in suppressing inflammation and regulating intestinal motility.
The study suggests Barberry Root could serve as a synergistic therapy for IBS-D, though further validation is needed.

Qi et al. (2025) studied this question.

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View Full Paper

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Authors

Computational integration and in vitro experiments uncover Barberry Root's impact on IBS-D, highlighting inflammation and neurotransmission pathways.

Barberry Root showed potential in alleviating IBS-D symptoms through multi-pathway regulation.
Fifteen bioactive compounds and 85 overlapping targets were identified, with strong binding affinities in molecular docking.
In vitro and in vivo experiments confirmed Barberry Root's role in suppressing inflammation and regulating intestinal motility.
The study suggests Barberry Root could serve as a synergistic therapy for IBS-D, though further validation is needed.

Qi et al. (2025) studied this question.

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