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June 20, 2026Brazilian Journal of OtorhinolaryngologyOpen Access

Role of vitamin D receptor and calcium sensing receptor in parathyroid cancer

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Authors

DZDongxue ZhangTZTeng ZhaoDBDehui Bi

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Overview

Randomized trial explores vitamin D receptor and calcium sensing receptor in parathyroid cancer, indicating their role in disease development.

Key Points

  • The study aims to evaluate the role of VDR and CaSR and their associated lncRNAs in the development and diagnosis of parathyroid cancer.
  • 12 patients with parathyroid cancer and 43 with parathyroid adenoma were enrolled.
  • Quantitative Real-Time Polymerase Chain Reaction (RT-qPCR) assessed mRNA expression of VDR and CaSR.
  • Immunofluorescence was used to evaluate protein levels of VDR and CaSR.
  • Decreased mRNA expression levels of VDR (p = 0.003) and CaSR (p = 0.000) were observed in parathyroid cancer patients.
  • lncRNA SLC2A1-DT (p = 0.004) and SLC22A5-AS1 (p = 0.002) expression levels increased in patients with normal serum phosphorus.
  • AUC for lncRNA SLC2A1-DT was 0.896 (p < 0.001) and for SLC22A5-AS1 was 0.920 (p < 0.001).

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a362fbcdb0793dc1a5371fahttps://doi.org/10.1016/j.bjorl.2026.101848
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Immunohistochemical Expression of CaSR, VDR, and AMA in Parathyroid Tumors Linked to Hypercalcemia Severity in Primary Hyperparathyroidism2025
  2. 2Receptor gene expressions and their association with biochemical parameters in primary hyperparathyroidism patients2025
  3. 3Megalin (LRP2) Expression Patterns in Prostate Cancer Stem Cells and Metastatic Subtypes: Implications for Tumor Progression and Metabolism2025
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  5. 5Up-regulation of intra-tumour LDLR gene expression is associated with statin treatment and better prostate cancer prognosis2025