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This research examines the expression patterns of LRP2 in prostate cancer and its implications for tumor progression.

December 8, 2025The Prostate

Megalin (LRP2) Expression Patterns in Prostate Cancer Stem Cells and Metastatic Subtypes: Implications for Tumor Progression and Metabolism

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Analysis shows LRP2 impacts metabolic pathways in prostate cancer stem cells, suggesting its role in metastasis.

This research examines the expression patterns of LRP2 in prostate cancer and its implications for tumor progression.
Analyzed LRP2 mRNA and protein in DU‐145, PC‐3, RWPE1 cells and their CD133 high/CD44 high cancer stem cells via qRT-PCR and immunofluorescence.
Utilized public RNA-seq data to assess LRP2, CD133, and CD44 across tumor types.
Conducted Gene Set Enrichment Analysis and correlation with AR, VDR, and stemness genes.
LRP2 was upregulated in DU‐145 cells and cancer stem cells in 3D culture systems.
PC‐3 cancer stem cells exhibited reduced LRP2 expression.
LRP2 levels were highest in metastatic tumors, particularly in bone and other metastatic subtypes.
CD133 downregulated in metastases; GSEA indicated LRP2's role in lipid, retinoid, and steroid metabolism.

Mukhtarova et al. (2025) studied this question.

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