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October 9, 2025Acta OncologicaOpen Access

Up-regulation of intra-tumour LDLR gene expression is associated with statin treatment and better prostate cancer prognosis

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Authors

KFKia Eistrup FonfaraJFJacob FredsøeBUBenedicte P. Ulhøi

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Overview

Observational analysis revealed increased LDLR expression in prostate cancer patients on statins, suggesting improved outcomes.

Key Points

  • Higher intra-tumour LDLR expression in prostate cancer patients was linked to statin use, indicating better prognosis.
  • Gene Set Enrichment Analysis showed 163 differentially expressed genes in prostate cancer samples, highlighting altered pathways.
  • The study utilized whole-transcriptome profiling from 186 radical prostatectomy specimens to assess gene expression patterns.
  • These findings support the potential benefits of statins in prostate cancer treatment through LDLR upregulation.

Cite This Study

Fonfara et al. (2025) studied this question.

synapsesocial.com/papers/68e70db290569dd607ee61bbhttps://doi.org/10.2340/1651-226x.2025.43788
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