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June 20, 2026Scientific ReportsOpen Access

Design of a triplex fluorescence aptasensor for a culture-free diagnosis of peritoneal dialysis-related peritonitis

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Authors

AAAwatef AltabbanARAmina RhouatiAAAreej I. Alhazmi

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Overview

Randomized trial demonstrates rapid diagnosis of peritonitis in dialysis, highlighting a novel culture-free approach.

Key Points

  • The aim is to develop a rapid, culture-free diagnostic tool for peritoneal dialysis-related peritonitis.
  • Developed a triplex fluorescence aptasensor for Staphylococcus aureus and Pseudomonas aeruginosa detection.
  • Utilized an unlabelled aptamer and fluorophore- and quencher-labeled complementary strands.
  • Tested sensor performance in sterilized clinical peritoneal fluid.
  • Aptasensors exhibited high sensitivity and specificity against non-target organisms.
  • Fluorescence restoration confirmed successful pathogen detection.
  • Demonstrated robust performance in clinical peritoneal fluid samples.

Cite This Study

Altabban et al. (2026) studied this question.

synapsesocial.com/papers/6a362de1db0793dc1a535d9bhttps://doi.org/10.1038/s41598-025-27637-y
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