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July 21, 2025Open Access

A Novel Aptamer Selection Strategy for Pseudomonas aeruginosa and Its Application as a Detecting Probe in a Hybrid Lateral Flow Assay

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Authors

TPThu Thao PhamNHNguyễn Thanh Thanh HuyềnLOLe Hong Oanh

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Overview

Whole-cell SELEX selected specific aptamers recognizing Pseudomonas aeruginosa, indicating potential for reliable diagnostics.

Key Points

  • Aptamer T1 was selected using a whole-cell SELEX strategy for its specific recognition of P. aeruginosa.
  • The hybrid lateral flow immunoassay achieved a detection limit of ~102 CFU/mL within 15 minutes.
  • A total of six aptamer candidates were evaluated, highlighting the efficient selection process.
  • Using aptamers could lead to low-cost and rapid diagnostics for bacterial infections, advancing point-of-care applications.

Cite This Study

Pham et al. (2025) studied this question.

synapsesocial.com/papers/689a060ee6551bb0af8cd0fchttps://doi.org/10.20944/preprints202507.1320.v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Novel Aptamer Selection Strategy for Pseudomonas aeruginosa and Its Application as a Detecting Probe in a Hybrid Lateral Flow Assay2025
  2. 2Aptamer Engineering: Strategies for Discovering Functional Nucleic Acids for Next‐Generation Diagnostics and Biosensing2025
  3. 3Design of a triplex fluorescence aptasensor for a culture-free diagnosis of peritoneal dialysis-related peritonitis2026
  4. 4Research Progress on Detection Technologies for Pseudomonas aeruginosa2025
  5. 5Enhanced sensitivity detection via orientational labelling of SPA-functionalized magnetic nanoparticles in lateral-flow immunoassays2025