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June 12, 2026European Journal of Preventive CardiologyOpen Access

Cardiac rehabilitation in non-ischaemic cardiomyopathies: functional, psychosocial, and structural benefits compared with coronary artery disease

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Why the study?

Does a centre-based cardiac rehabilitation programme improve peak oxygen uptake and functional capacity in patients with non-ischaemic cardiomyopathies?

Population

606 consecutive patients who completed a centre-based cardiac rehabilitation programme, including coronary…

Design

Cohort

Authors

MSM StiefelCRC A RuestHSH Brito Da Silva

Discussion

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Overview

May support CR referral in non-ischaemic cardiomyopathy; hypothesis-generating for etiology-specific responses.

Key Points

  • The study aims to assess the benefits of cardiac rehabilitation in patients with non-ischaemic cardiomyopathies compared to those with coronary artery disease.
  • Retrospective analysis of 606 patients completing a cardiac rehabilitation programme from 2011 to 2025.
  • Inclusion of patients with coronary artery disease and various types of non-ischaemic cardiomyopathies.
  • Primary endpoint was change in peak oxygen uptake, with multiple secondary endpoints related to physical and psychological health.
  • VO2peak improved by +2.7 mL·kg−¹·min−¹ overall (p<0.001), with lower gain in NDLVC (+0.8 vs CAD +3.0; p=0.003).
  • 6MWT increased by +51 m overall, greatest improvements seen in CAD and DCM groups.
  • Psychological measures improved (PHQ-8 -0.8, GAD-7 -0.6; both p<0.01) and NT-proBNP decreased significantly in DCM.

Structured PICO

Does a centre-based cardiac rehabilitation programme improve peak oxygen uptake and functional capacity in patients with non-ischaemic cardiomyopathies?

P
Population
606 consecutive patients who completed a centre-based cardiac rehabilitation programme, including coronary artery disease (n=398), dilated cardiomyopathy (n=59), non-dilated left ventricular cardiomyopathy (n=49), and hypertrophic cardiomyopathy (n=19).
I
Intervention
Centre-based cardiac rehabilitation (CR) programme
O
Outcome
Change in peak oxygen uptake (VO2peak)surrogate

Cardiac rehabilitation provides significant functional, structural, and psychosocial benefits in patients with non-ischaemic cardiomyopathies, supporting its routine integration into their clinical management.

Limitations

  • Retrospective design

Cite This Study

Stiefel et al. (2026) studied this question.

synapsesocial.com/papers/6a2bd11d6550ea4541ffe898https://doi.org/10.1093/eurjpc/zwag249.330
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiac rehabilitation outcomes in heart failure: insights from echocardiographic deformation parameters2026
  2. 2Changes in functional capacity after a contemporary cardiac rehabilitation program: results from the ReCardio national registry2026
  3. 3Comparison of different aerobic exercise modalities on echocardiographic variables in early cardiac rehabilitation2026
  4. 4Cardiac rehabilitation for workers with ischemic heart disease: Benefits for cardiovascular health and quality of life2025 · 1 citations
  5. 5Effectiveness of comprehensive outpatient cardiac rehabilitation among heart failure patients in a developing country2026