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June 12, 2026European Journal of Preventive CardiologyOpen Access

Cardiac rehabilitation outcomes in heart failure: insights from echocardiographic deformation parameters

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Why the study?

Does a 12-week cardiac rehabilitation program improve echocardiographic deformation parameters, functional status, and biomarkers in patients with heart failure?

Population

100 patients with heart failure admitted to a specialized cardiac rehabilitation center, categorized by…

Comparison

12-week cardiac rehabilitation program… vs Patients with mild-moderate functional…

Design

Cohort

Follow-up

6 months

Key result

Cardiac rehabilitation in heart failure patients yielded greater NT-proBNP reductions in those with moderate-severe versus mild-moderate functional limitation (-61.22 vs -49.25 pg/ml; P=0.024).

Authors

CAC AdamMLM M LeonMFM Florin

Discussion

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Overview

CR may improve filling pressures and function in HF; hypothesis-generating, requiring RCTs before any practice change.

Key Points

  • This study assesses the effects of cardiac rehabilitation on echocardiographic parameters and biological markers in heart failure patients.
  • Prospective cohort study with 100 heart failure patients enrolled in a cardiac rehabilitation program for 6 months.
  • Participants underwent cardiopulmonary exercise testing for functional classification and received tailored aerobic and resistance training sessions.
  • Data including NT-proBNP, echocardiographic parameters, and quality of life assessments were collected at baseline and after 6 months.
  • Patients with moderate-severe limitation showed a greater reduction in NT-proBNP (-61.22 pg/ml vs. -49.25 pg/ml, p=0.024) and improved echocardiographic parameters like LV GLS (0.79 vs. -0.92, p=0.039).
  • A significant correlation was found between LV GLS and NT-proBNP (p=0.019) and peak oxygen uptake (p=0.037).
  • An LV GLS value of less than -10.3% served as a negative predictor for functional improvement (AUC 0.750, p<0.001).

Study Design

Type

Cohort (n=100)

Multicenter

No

Structured PICO

Does a 12-week cardiac rehabilitation program improve echocardiographic deformation parameters, functional status, and biomarkers in patients with heart failure?

P
Population
100 patients with heart failure (mean ejection fraction 43.15%) admitted to a specialized cardiac rehabilitation center, followed for 6 months.
E
Exposure
12-week cardiac rehabilitation program (5 sessions per week) consisting of individualized aerobic and resistance training tailored according to cardiopulmonary exercise testing (CPET) results.
C
Comparator
Patients with mild-moderate functional limitation (comparing moderate-severe vs mild-moderate groups) and baseline values.
O
Outcome
Changes in biological markers (NT-proBNP, hs-CRP, lipid profile), functional status, and echocardiographic parameters (LV/RV global longitudinal strain, left atrial reservoir strain) at 6 months.surrogate

Main Result

Absolute Event Rate: -61.22% vs -49.25%

p-value: p=0.024

A 12-week cardiac rehabilitation program significantly improves echocardiographic deformation parameters and biomarkers in heart failure patients, particularly those with more severe baseline functional limitations.

Cite This Study

Adam et al. (2026) conducted a cohort in Heart failure (n=100). Moderate-severe functional limitation (undergoing cardiac rehabilitation) vs. Mild-moderate functional limitation was evaluated on Change in NT-proBNP levels (pg/ml) (p=0.024). Cardiac rehabilitation in heart failure patients yielded greater NT-proBNP reductions in those with moderate-severe versus mild-moderate functional limitation (-61.22 vs -49.25 pg/ml; P=0.024).

synapsesocial.com/papers/6a2bd11d6550ea4541ffe86ahttps://doi.org/10.1093/eurjpc/zwag249.045
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiac rehabilitation in non-ischaemic cardiomyopathies: functional, psychosocial, and structural benefits compared with coronary artery disease2026
  2. 2Effectiveness of comprehensive outpatient cardiac rehabilitation among heart failure patients in a developing country2026
  3. 3Comparison of different aerobic exercise modalities on echocardiographic variables in early cardiac rehabilitation2026
  4. 4The Impact of Continuous Cardiac Rehabilitation on the Psychological and Physiological Prognosis of Patients with Heart Failure—A Retrospective Study2025
  5. 5Cardiac rehabilitation for workers with ischemic heart disease: Benefits for cardiovascular health and quality of life2025 · 1 citations