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June 7, 2026Diabetes

2184-P: CGM-Derived Measures in Relation to 10-Year CVD Risk in Adults without Diabetes

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Why the study?

Do CGM-derived measures and 2-h post-MMTT glucose associate with estimated 10-year CVD risk in adults without diabetes?

Population

1374 Framingham Heart Study participants free of diabetes and CVD, mean age 59.3y, 55.8% female, 56%…

Design

Cross-sectional

Authors

BBBahar BakhshiVXVanessa XanthakisHLHonghuang Lin

Discussion

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Overview

Dynamic measures of glycemia, such as CGM-derived metrics and post-MMTT glucose, are associated with higher estimated 10-year CVD risk in adults without diabetes, independent of fasting plasma glucose.

Key Points

  • This research investigates the relationship between glucose fluctuations and cardiovascular disease (CVD) risk in adults without diabetes.
  • Included 1374 Framingham Heart Study participants free of diabetes and CVD, with ≥3 days of CGM data.
  • Used multinomial regression to analyze GLU levels and PREVENT categories, adjusting for fasting plasma glucose.
  • Estimated CVD risk with PREVENT equations for 10-year outcomes.
  • Higher 2-h post-MMTT glucose correlated with increased odds of intermediate/high CVD risk (ORs: 1.21-1.70, p<0.001).
  • Each 1 SD increase in CGM-derived measures resulted in a higher overall 10-year CVD risk (β:0.07-0.16, p<0.001).

Structured PICO

Do CGM-derived measures and 2-h post-MMTT glucose associate with estimated 10-year CVD risk in adults without diabetes?

P
Population
1374 Framingham Heart Study participants free of diabetes and CVD (3rd Generation, Exam 4), mean age 59.3y, 55.8% female, 56% normoglycemic. Key inclusion: ≥3 days of continuous glucose monitor (CGM) and completed a mixed meal tolerance test (600kcal MMTT; 75g carbohydrate, 21g fat, 29g protein).
I
Intervention
Standardized CGM-derived measures (including mean glucose and time >140mg/dL) and 2-h post-MMTT glucose
O
Outcome
10-year total CVD risk estimated using the Predicting Risk of CVD EVENTs (PREVENT) base equationssurrogate

Dynamic measures of glycemia, such as CGM-derived metrics and post-MMTT glucose, are associated with higher estimated 10-year CVD risk in adults without diabetes, independent of fasting plasma glucose.

Cite This Study

Bakhshi et al. (2026) studied this question.

synapsesocial.com/papers/6a250baa7def13d035e1bb70https://doi.org/10.2337/db26-2184-p
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 11929-P: Assessing Glycemic Variability by Continuous Glucose Monitoring: Implications for Prediabetes Subtypes and Potential Cardiovascular Risk2026
  2. 22962-LB: CGM Metrics and Cardiovascular and Mortality Outcomes in Type 2 Diabetes: Data from the GRADE-CGM Substudy2026
  3. 32090-P: High Day-to-Day Glycemic Variability in Youth-Onset Type 2 Diabetes2026
  4. 42965-LB: Cardiovascular Disease Risk Prediction in Type 1 Diabetes over 30 Years2026
  5. 51942-P: Hyperglycemia Metrics from Continuous Glucose Monitoring Are Independently Associated with Platelet Morphology in Adults with Type 1 Diabetes2026