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June 12, 2026Diabetes

In youth-onset type 2 diabetes, glycemic variability was high and correlated with HbA1c, while insulin therapy was associated with higher glucose standard deviation (46 vs. 24 mg/dL, P<0.01).

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Population

52 youth-onset type 2 diabetes participants enrolled in clinical trials between 2021-2025, mean age 17.0±4.4…

Design

Cohort

Follow-up

7-10 days

Key result

In youth-onset type 2 diabetes, glycemic variability was high and correlated with HbA1c, while insulin therapy was associated with higher glucose standard deviation (46 vs. 24 mg/dL, P<0.01).

Authors

NRNicole RangosIKILA N. KACKERMGMADILYN M. GAYDOS

Discussion

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Overview

GV assessment may aid risk stratification in Y-T2D on insulin; leaves open whether targeting variability improves CVD outcomes.

Key Points

  • The aim was to characterize glycemic variability in youth-onset type 2 diabetes (Y-T2D) and its relationship with cardiovascular risk factors.
  • Pooled cohort analysis of Y-T2D participants in clinical trials (2021-2025)
  • Glycemic variability measured by glucose standard deviation and mean of daily differences using Dexcom CGM over 7-10 days
  • Correlations assessed with Spearman’s and regression adjusted for age and BMI.
  • Glycemic variability was high, with SD of 27 mg/dL and MODD of 25 mg/dL
  • A 1% increase in HbA1c was associated with an increase in glycemic variability of ~3 mg/dL
  • Insulin therapy linked to higher HbA1c (10.8 vs. 6%, P<0.01), SD (46 vs. 24 mg/dl, P<0.01), and MODD (46 vs. 22 mg/dl, P<0.01).

Study Design

Type

Cohort (n=52)

Structured PICO

P
Population
52 youth with type 2 diabetes (mean age 17.0 years, 67% female) who underwent continuous glucose monitoring for 7-10 days.
E
Exposure
Continuous glucose monitoring (Dexcom CGM) over 7-10 days to measure glycemic variability.
O
Outcome
Glycemic variability within a day (measured by glucose standard deviation [SD]) and between days (measured with mean of daily differences [MODD]), and its relationship with contemporaneous HbA1c.surrogate

Youth-onset type 2 diabetes is associated with high day-to-day glycemic variability, which correlates with HbA1c and is highest in patients on insulin therapy, highlighting a potential independent risk factor for cardiovascular disease.

Cite This Study

Rangos et al. (2026) conducted a cohort in Youth-onset type 2 diabetes (n=52). Glycemic variability was evaluated on Glycemic variability (SD and MODD) and its relationship with HbA1c. In youth-onset type 2 diabetes, glycemic variability was high and correlated with HbA1c, while insulin therapy was associated with higher glucose standard deviation (46 vs. 24 mg/dL, P<0.01).

synapsesocial.com/papers/6a2bd11d6550ea4541ffe8ebhttps://doi.org/10.2337/db26-2090-p
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