Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 7, 2026Diabetes

Peak glucose, standard deviation, coefficient of variation, and time above 140 mg/dL were significantly higher in prediabetes than NGT (151 vs 126 mg/dL; 16 vs 10 mg/dL; 0.16 vs 0.10; and 12 vs 0.2% respectively, all p<0.05).

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does continuous glucose monitoring identify differences in glycemic variability between prediabetes subtypes and normal glucose tolerance?

Population

49 participants divided into Normal Glucose Tolerance, Isolated Impaired Fasting Glucose, Isolated Impaired…

Comparison

Continuous glucose monitoring (CGM) for 5 days vs Normal Glucose Tolerance (NGT)

Design

Cross-sectional

Follow-up

5 days

Authors

PMPapanun MahapolAMAurora MerovciSRSAVIA V. ROSEMBARQUE

Discussion

Loading...

Member takes

Overview

Continuous glucose monitoring reveals that individuals with prediabetes have significantly higher glycemic variability than those with normal glucose tolerance, despite similar mean glucose levels.

Key Points

  • The study aims to investigate glycemic variability in different prediabetes subtypes using continuous glucose monitoring.
  • 49 participants underwent a 2-hour oral glucose tolerance test and euglycemic insulin clamp.
  • Subjects were categorized into four groups based on OGTT glucose profiles: NGT, IFG, IGT, CGI.
  • Five days of continuous glucose monitoring were performed to assess glycemic variability indices.
  • CGM indicated that mean glucose levels were similar between prediabetes and NGT (98±16 vs 98±8 mg/dL).
  • Significantly higher peak glucose, SD, CV, and time above 140 mg/dL were found in prediabetes compared to NGT, all p<0.05.
  • In CGI, CGM mean glucose showed a negative correlation with Disposition Index (r= -0.381, p<0.05).

Structured PICO

Does continuous glucose monitoring identify differences in glycemic variability between prediabetes subtypes and normal glucose tolerance?

P
Population
49 participants divided into Normal Glucose Tolerance (NGT, n=6), Isolated Impaired Fasting Glucose (IFG, n=9), Isolated Impaired Glucose Tolerance (IGT, n=4), and Combined IFG and IGT (CGI, n=30).
I
Intervention
Continuous glucose monitoring (CGM) for 5 days
C
Comparator
Normal Glucose Tolerance (NGT)
O
Outcome
Glycemic variability indices (mean glucose, peak glucose, standard deviation, coefficient of variation, and time above 140 mg/dL)surrogate

Continuous glucose monitoring reveals that individuals with prediabetes have significantly higher glycemic variability than those with normal glucose tolerance, despite similar mean glucose levels.

Cite This Study

Mahapol et al. (2026) studied this question.

synapsesocial.com/papers/6a250b2d7def13d035e1b361https://doi.org/10.2337/db26-1929-p
View Full Paper
Ask AI
Bookmark
Share