Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 7, 2026Diabetes

Mediation analysis showed that approximately 28.5% of the total effect of age on CV risk accumulation was mediated through increasing BMI, with age significantly associated with both BMI (β=0.247 per year, p<0.001) and CV risk count (β=0.0288 per year, p<0.001).

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does rising BMI mediate the age-related increase in cardiovascular risk in patients with Type 1 Diabetes?

Population

1,266 patients living with Type 1 Diabetes (T1D), 52.1% male.

Design

Cohort

Authors

EAElamin AbdelgadirDODarin OsborneJSJÖRN M. SCHATTENBERG

Discussion

Loading...

Member takes

Overview

Rising adiposity mediates a substantial portion (28.5%) of the age-related increase in cardiovascular risk among patients with Type 1 Diabetes, highlighting the importance of weight management.

Key Points

  • The aim is to assess if rising BMI explains the increase in cardiovascular risk associated with age in individuals with type 1 diabetes (T1D).
  • Analyzed data from 1,266 patients with T1D, including 52.1% males.
  • Defined cardiovascular risk as a combination of hypertension, dyslipidemia, obesity, smoking, and microvascular complications.
  • Employed mediation analysis to evaluate the relationship between age, BMI, and cardiovascular risk.
  • Observed a 2.5-fold increase in CV risk accumulation rate after age 35.
  • Age showed significant relationships with both BMI (β=0.247, p<0.001) and CV risk count (β=0.0288, p<0.001).
  • Approximately 28.5% of the age effect on CV risk was mediated through BMI increases.

Structured PICO

Does rising BMI mediate the age-related increase in cardiovascular risk in patients with Type 1 Diabetes?

P
Population
1,266 patients living with Type 1 Diabetes (T1D), 52.1% male.
I
Intervention
Rising BMI / Age (observational exposure)
O
Outcome
Cardiovascular risk count (composite of hypertension, dyslipidemia, obesity, smoking, and microvascular complications)composite

Rising adiposity mediates a substantial portion (28.5%) of the age-related increase in cardiovascular risk among patients with Type 1 Diabetes, highlighting the importance of weight management.

Cite This Study

Abdelgadir et al. (2026) studied this question.

synapsesocial.com/papers/6a250b707def13d035e1b6dehttps://doi.org/10.2337/db26-2961-lb
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 12983-LB: Trajectories of Risk Factors among Participants with Long-Duration Type 1 Diabetes2026
  2. 22708-LB: Integrated Cardiovascular Risk Assessment in Young Adults with Type 2 Diabetes: The “YOUNG DIABETES” Program2026
  3. 31404-P: Obesity Drives Cardiac Hypertrophy while Diabetic Kidney Disease Links to Myocardial Edema and Vascular Stiffness in Young Adults with Type 2 Diabetes2026
  4. 42965-LB: Cardiovascular Disease Risk Prediction in Type 1 Diabetes over 30 Years2026
  5. 52231-P: RECLASS-T1D: Real-World Evaluation of AABBCC Criteria for Diabetes Classification: Experience from 6.7 Million U.S. Patients2026