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June 7, 2026Diabetes

2401-P: Genetic Regulation of Molecular Traits Enhances Precision Risk Stratification in Youth-Onset Type 2 Diabetes

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Population

355 participants with youth-onset type 2 diabetes (YT2D) from the TODAY study

Design

Cohort

Follow-up

12.4 ± 1.2 yrs

Authors

MDMatteo D’AntonioPBPETTER BJORNSTADYCYe Ji Choi

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Overview

Integration of genomics, proteomics, and metabolomics can accurately predict long-term cardiorenal and metabolic complications in youth-onset type 2 diabetes.

Key Points

  • The aim is to identify molecular drivers of youth-onset type 2 diabetes for early detection and care.
  • Integrated whole-exome sequencing, proteomics, and metabolomics in 355 TODAY participants.
  • Colocalization with GWAS for T2D-related traits to assess shared causal variants.
  • Used Cox models and cross-validation predictive techniques on molecular data.
  • Identified 1,119 QTLs at 407 genomic loci.
  • Linked 528 QTLs to 19 incident outcomes, with eight comorbidities predicted accurately (C-index >0.7).
  • Revealed 25 YT2D-related traits sharing causal variants with QTLs, identifying key biological pathways.

Structured PICO

P
Population
355 participants with youth-onset type 2 diabetes (YT2D) from the TODAY study
O
Outcome
19 incident comorbidities (including rapid eGFR decline and hyperfiltration)

Integration of genomics, proteomics, and metabolomics can accurately predict long-term cardiorenal and metabolic complications in youth-onset type 2 diabetes.

Cite This Study

D’Antonio et al. (2026) studied this question.

synapsesocial.com/papers/6a250ae37def13d035e1af5dhttps://doi.org/10.2337/db26-2401-p
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 11136-OR: Longitudinal Time-to-Event Modeling and Identification of Risk Factors for the Occurrence of Microvascular Complications in Youth-Onset Type 2 Diabetes2026
  2. 22223-P: Harnessing Machine Learning to Forecast Two-Year Progression to Stage 3 Type 1 Diabetes (T1D) in Individuals with Multiple Type 1 Diabetes Autoantibodies: A Noise-Resistant, Multidimensional Clustering Approach2026
  3. 31404-P: Obesity Drives Cardiac Hypertrophy while Diabetic Kidney Disease Links to Myocardial Edema and Vascular Stiffness in Young Adults with Type 2 Diabetes2026
  4. 42335-P: Metabolomic Analysis Reveals That Prediabetes Subgroups Have Different Likelihoods of T2D Onset: A Definition, Etiology, and Function: Integration to Enhance T2D Treatment (DEFINE-T2D) Consortium Analysis2026
  5. 52708-LB: Integrated Cardiovascular Risk Assessment in Young Adults with Type 2 Diabetes: The “YOUNG DIABETES” Program2026