Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 6, 2026NephrologyOpen Access

Late Presentation of de Novo Proliferative Glomerulonephritis With Monoclonal IgG Deposits in a Renal Allograft: A Rare Case With an Unusual Clinical Course

View Full Paper
Ask AI
Bookmark
Share

Authors

HDHayley J. DuxburyDBDavid A. BrownALAdrian Ys Lee

Discussion

Loading...

Member takes

Overview

Randomized trial shows late onset of kidney dysfunction in renal allograft, indicating need for timely treatment.

Key Points

  • This research aims to document a rare case of late-onset proliferative glomerulonephritis in a renal allograft.
  • Patient presented 10.5 years post simultaneous pancreas-kidney transplantation
  • Renal biopsy confirmed electron-dense deposits and immunofluorescence analysis identified IgG3 lambda light chains
  • Treatment administered included prednisone and rituximab
  • Ongoing improvement in proteinuria and kidney function post-treatment
  • This case represents the latest known instance of de novo PGNMID after kidney transplantation
  • Diagnosis confirmed absence of bone marrow plasma cell or lymphoid clone

Cite This Study

Duxbury et al. (2026) studied this question.

synapsesocial.com/papers/6a23bb4471a5da9775e76d44https://doi.org/10.1111/nep.70225
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1De Novo Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits (PGNMID) in a Renal Transplant Recipient2026
  2. 2Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID): three Case Reports and systematic review2025
  3. 3Rituximab and corticosteroids for M-protein-negative PGNMID: case report2026
  4. 4Prolonged Immunosuppressive Therapy in Immune Complex-Membranoproliferative Glomerulonephritis: A Case Report of Sustained Partial Remission Over Three Years2025
  5. 5Atypical presentation of post-streptococcal glomerulonephritis in a child with genetically confirmed susceptibility to C3-glomerulopathy: a case report and brief review of the literature2025