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September 5, 2025BMC NephrologyOpen Access

Atypical presentation of post-streptococcal glomerulonephritis in a child with genetically confirmed susceptibility to C3-glomerulopathy: a case report and brief review of the literature

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Authors

CKCharalampos KapogiannisAKAnastasios KapogiannisDZDiagoras Zarganis

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Overview

Case report details atypical PSGN's overlap with C3 glomerulopathy in a child, suggesting immunological implications.

Key Points

  • A 2.5-year-old girl presented with acute kidney injury and nephrotic range proteinuria, indicating PSGN.
  • Genetic testing confirmed a rare polymorphism in the THBD gene associated with C3 glomerulopathy.
  • Kidney biopsy revealed strong C3 deposition, complicating the diagnosis between PSGN and C3G.
  • Corticosteroid treatment led to normalization of C3 levels and improvement of symptoms.

Cite This Study

Kapogiannis et al. (2025) studied this question.

synapsesocial.com/papers/68c239e5b210217d6477df8bhttps://doi.org/10.1186/s12882-025-04437-0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1C3 glomerulopathy triggered by infection-A rare case report2025
  2. 2Acute Post‐Streptococcal Glomerulonephritis in a 22‐Month‐Old Toddler: A Rare and Uncustomary Age of Onset2025
  3. 3Clinical Presentation, Treatment Patterns, Burden of Disease and the Association of Proteinuria with Clinical Outcomes in C3 Glomerulopathy and Primary Immune Complex Membranoproliferative Glomerulonephritis: A Systematic Review2025
  4. 4Late Presentation of <i>de Novo</i> Proliferative Glomerulonephritis With Monoclonal <scp>IgG</scp> Deposits in a Renal Allograft: A Rare Case With an Unusual Clinical Course2026
  5. 5Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID): three Case Reports and systematic review2025