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September 16, 2025Frontiers in MedicineOpen Access

Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID): three Case Reports and systematic review

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Authors

QJQingwei JiSYShuyuan YuXZXia Zhou

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Overview

Retrospective analysis reveals treatment options and common presentations for proliferative glomerulonephritis with monoclonal immunoglobulin deposits.

Key Points

  • Patients with proliferative glomerulonephritis with monoclonal immunoglobulin deposits present with significant proteinuria and hematuria.
  • The IgG3κ subtype is most prevalent in patients with membranoproliferative glomerulonephritis noted in light microscopy.
  • Current guidelines advocate for the BCD regimen as the first-line therapy for this condition.
  • Clinical decision-making should consider patient-specific factors such as age and renal function for treatment efficacy.

Cite This Study

Ji et al. (2025) studied this question.

synapsesocial.com/papers/68d42321713b0b5dfea6ae80https://doi.org/10.3389/fmed.2025.1637435
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Late Presentation of <i>de Novo</i> Proliferative Glomerulonephritis With Monoclonal <scp>IgG</scp> Deposits in a Renal Allograft: A Rare Case With an Unusual Clinical Course2026
  2. 2De Novo Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits (PGNMID) in a Renal Transplant Recipient2026
  3. 3Rituximab and corticosteroids for M-protein-negative PGNMID: case report2026
  4. 4Prolonged Immunosuppressive Therapy in Immune Complex-Membranoproliferative Glomerulonephritis: A Case Report of Sustained Partial Remission Over Three Years2025
  5. 5Evaluation of Adult Patients Diagnosed with Idiopathic Membranous Glomerulonephritis: A Single-Center Retrospective Study2025