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July 26, 2026BMC NephrologyOpen Access

Rituximab and corticosteroids for M-protein-negative PGNMID: case report

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Authors

ZHZixing HuangSYShuopeng YangJCJun Cai

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Overview

Case report demonstrates improved renal function in a 69-year-old with M-protein-negative PGNMID after treatment.

Key Points

  • To explore the potential benefits of rituximab and corticosteroids in a patient with M-protein-negative PGNMID.
  • Renal biopsy confirmed diagnosis of PGNMID
  • Administered a single dose of rituximab due to pulmonary infection
  • Utilized long-term corticosteroid maintenance after infection resolution.
  • Renal function improved with serum creatinine decreasing from 914 to 134 µmol/L
  • Causality between treatment and improvement remains uncertain
  • Suggests potential for B-cell directed therapy in seronegative PGNMID.

Cite This Study

Huang et al. (2026) studied this question.

synapsesocial.com/papers/6a65a8c9d3aea3239cd78fe4https://doi.org/10.1186/s12882-026-05225-0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID): three Case Reports and systematic review2025
  2. 2Late Presentation of <i>de Novo</i> Proliferative Glomerulonephritis With Monoclonal <scp>IgG</scp> Deposits in a Renal Allograft: A Rare Case With an Unusual Clinical Course2026
  3. 3De Novo Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits (PGNMID) in a Renal Transplant Recipient2026
  4. 4Prolonged Immunosuppressive Therapy in Immune Complex-Membranoproliferative Glomerulonephritis: A Case Report of Sustained Partial Remission Over Three Years2025
  5. 5Evaluation of Adult Patients Diagnosed with Idiopathic Membranous Glomerulonephritis: A Single-Center Retrospective Study2025