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June 6, 2026Annals of Clinical Microbiology and AntimicrobialsOpen Access

Associations of Mycoplasma pneumoniae load, co-infections, and macrolide resistance with clinical-laboratory profiles in hospitalized pediatric pneumonia: a targeted next-generation sequencing study of bronchoalveolar lavage fluid

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Authors

梁梁杏珍RWRong WeiDLDongna Liang

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Overview

Retrospective cohort study evaluates associations of Mycoplasma pneumoniae load and resistance in hospitalized children, suggesting implications for treatment strategies.

Key Points

  • This study evaluates the relationships between Mycoplasma pneumoniae DNA load, co-infections, and macrolide resistance in children with pneumonia.
  • Conducted a retrospective cohort study of 791 hospitalized children with Mycoplasma pneumoniae pneumonia.
  • Utilized targeted next-generation sequencing of bronchoalveolar lavage fluid for MP DNA load and resistance profiling.
  • Analyzed clinical data for associations with the sequencing parameters using statistical methods.
  • High MP DNA load correlates with persistent fever and lung consolidation in monoinfection.
  • Low MP DNA load indicates a co-infection syndrome in younger children with severe respiratory symptoms.
  • Macrolide-resistant Mycoplasma pneumoniae increases the odds of treatment failure three-fold, with no impact on initial disease severity.

Cite This Study

梁杏珍 et al. (2026) studied this question.

synapsesocial.com/papers/6a23b9f271a5da9775e75affhttps://doi.org/10.1186/s12941-026-00870-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of Macrolide Resistance and Mycoplasma pneumoniae DNA Load in Bronchoalveolar Lavage Fluid on Immune and Inflammatory Responses in Children with Mycoplasma pneumoniae Pneumonia2025
  2. 2Targeted next-generation sequencing reveals pathogen mono- and co-detection patterns in pediatric Mycoplasma pneumoniae pneumonia2025 · 4 citations
  3. 3Comparative study of clinical characteristics and long-term prognosis between macrolide-resistant and macrolide-sensitive Mycoplasma pneumoniae infections in children: A retrospective case-control study2025
  4. 4Detection of pathogens and epidemiological characteristics of community-acquired pneumonia in children using metagenomic next-generation sequencing2025
  5. 5Clinical features of MPP with or without viruses among hospitalized children in 2023, Wenzhou, Zhejiang, China2025