Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 25, 2025Indian PediatricsOpen Access

Effect of Macrolide Resistance and Mycoplasma pneumoniae DNA Load in Bronchoalveolar Lavage Fluid on Immune and Inflammatory Responses in Children with Mycoplasma pneumoniae Pneumonia

View Full Paper
Ask AI
Bookmark
Share

Authors

HZHaiqin ZhongZZZeyu ZengHGHaoxiang Gu

Discussion

Loading...

Member takes

Overview

Retrospective analysis shows macrolide resistance and high MP-DNA load worsen inflammatory responses in children, indicating urgent treatment adjustments.

Key Points

  • Macrolide-resistant Mycoplasma pneumoniae leads to higher inflammation and immune dysregulation in children.
  • Among resistant cases, those with high DNA loads had significantly elevated BALF cytokine levels.
  • Patients with macrolide resistance experienced longer fever duration and hospital stays due to compounded inflammation.
  • Detection of resistance early can guide more effective antibiotic treatments and improve clinical outcomes.

Cite This Study

Zhong et al. (2025) studied this question.

synapsesocial.com/papers/68d5da9cddad3c16d4636a8bhttps://doi.org/10.1007/s13312-025-00190-7
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Associations of Mycoplasma pneumoniae load, co-infections, and macrolide resistance with clinical-laboratory profiles in hospitalized pediatric pneumonia: a targeted next-generation sequencing study of bronchoalveolar lavage fluid2026
  2. 2Comparative study of clinical characteristics and long-term prognosis between macrolide-resistant and macrolide-sensitive Mycoplasma pneumoniae infections in children: A retrospective case-control study2025
  3. 3[Characteristics of bronchoalveolar lavage fluid microbial distribution at different disease stages and its relationship with immune function in children with refractory 2025
  4. 4Risk Factors and Clinical Characteristics of Fulminant Mycoplasma pneumoniae Pneumonia in Children: A Retrospective Case‒Control Study2025
  5. 5Dynamic changes of pulmonary function and immune function in children with mycoplasma pneumonia of different severity and their predictive value for disease prognosis: a retrospective cohort study2025