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September 18, 2025Infection Genetics and EvolutionOpen Access

Targeted next-generation sequencing reveals pathogen mono- and co-detection patterns in pediatric Mycoplasma pneumoniae pneumonia

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Authors

GWGuangliang WuYZYuejie ZhengKYKe Yuan

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Overview

Retrospective analysis illustrates pathogen co-detection and drug resistance in children with pneumonia, highlighting benefits of next-generation sequencing.

Key Points

  • Pathogen detection rates were extremely high, with 99.7% of cases identifying at least one pathogen present.
  • Mycoplasma pneumoniae accounted for 85% of detected pathogens, indicating its prominence in pediatric pneumonia.
  • Age differences were significant, with MP-positive patients being older (median 72 months) than MP-carriage and MP-negative groups.
  • The study found a resurgence of MP despite lower macrolide resistance rates compared to historical data.

Cite This Study

Wu et al. (2025) studied this question.

synapsesocial.com/papers/68d435cf713b0b5dfea7507chttps://doi.org/10.1016/j.meegid.2025.105832
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Associations of Mycoplasma pneumoniae load, co-infections, and macrolide resistance with clinical-laboratory profiles in hospitalized pediatric pneumonia: a targeted next-generation sequencing study of bronchoalveolar lavage fluid2026
  2. 2Clinical features of MPP with or without viruses among hospitalized children in 2023, Wenzhou, Zhejiang, China2025
  3. 3Mycoplasma pneumoniae Pneumonia: Variety of Presentation in Children Case Series2025
  4. 4Analysis of Bacterial Isolates from a Large Tertiary Children's Hospital in Beijing, China, During the Mycoplasma Outbreak in 20232026
  5. 5Epidemiology and Clinical Impact of Mycoplasma pneumoniae in an Italian Pediatric Center: An Observational Study from 2017 to 20242025 · 6 citations