Detection of pathogens and epidemiological characteristics of community-acquired pneumonia in children using metagenomic next-generation sequencing

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Retrospective analysis shows mNGS detects pathogens better than culture in children with pneumonia, suggesting enhanced clinical outcomes.

mNGS improves pathogen detection rates in children with community-acquired pneumonia compared to culture.
The predominant pathogen is Mycoplasma pneumoniae, especially in older children.
Cytomegalovirus primarily affects infants, while other pathogens vary by season.
Data analyzed from bronchoalveolar lavage fluid and sputum samples for accurate detection.

Deng et al. (2025) studied this question.

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Retrospective analysis shows mNGS detects pathogens better than culture in children with pneumonia, suggesting enhanced clinical outcomes.