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May 22, 2026Natural Product CommunicationsOpen Access

Natural Compounds Targeting Profibrotic Signaling Pathways in Myocardial Fibrosis: Signaling Network Regulation and Therapeutic Potential

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Population

Myocardial fibrosis in various cardiac diseases, including myocardial infarction, hypertensive heart…

Design

Review

Authors

YLYanxin LiLZLuwen ZhangMLM Li

Discussion

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Overview

May offer adjunctive options for MF with limited therapies; extends preclinical signals but requires confirmatory RCTs.

Structured PICO

P
Population
Myocardial fibrosis (MF) in various cardiac diseases, including myocardial infarction (MI), hypertensive heart disease, and dilated cardiomyopathy
I
Intervention
Natural compounds (e.g., Salvianolic acid B, Astragaloside IV, Pachymic acid, Resveratrol, Curcumin, Matrine, Artemisinin, and Artesunate)

Natural compounds show therapeutic potential for myocardial fibrosis by regulating profibrotic signaling pathways, though clinical translation requires further pharmacokinetic and clinical trial data.

Limitations

  • Lack of comprehensive data on pharmacokinetics, bioavailability, long-term safety, and clinical efficacy

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff3ecd674f7c03778ce68https://doi.org/10.1177/1934578x261454083
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Targeting inhibition of the inflammatory response: advances in the treatment of myocardial fibrosis with natural medicine and active ingredients2025 · 2 citations
  2. 2Therapeutic Targets for Myocardial Fibrosis: A Comprehensive Review of Current and Emerging Approaches2025
  3. 3Rewiring the scar: translational advances in cardiac fibrosis.2025 · 4 citations
  4. 4miRNA-Orchestrated Fibroinflammatory Responses in Heart Failure with Preserved Ejection Fraction: Translational Opportunities for Precision Medicine2025
  5. 5Intercellular Targetable Mechanistic Interface for Cardiac Fibrosis2026