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September 12, 2025DiagnosticsOpen Access

miRNA-Orchestrated Fibroinflammatory Responses in Heart Failure with Preserved Ejection Fraction: Translational Opportunities for Precision Medicine

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Authors

MMMihaela MicuDCDan Alexandru CozacASAlina Scridon

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Overview

This review uncovers miRNA contributions to inflammation and fibrosis in heart failure, suggesting new therapeutic pathways.

Key Points

  • Recent findings show that specific miRNAs, such as miR-21 and miR-29, significantly influence inflammation and fibrosis in heart failure.
  • Understanding the inflammation-fibrosis axis reveals potential therapeutic avenues to modify disease progression in heart failure.
  • Exploration of miRNA as biomarkers could enhance diagnostic and prognostic capabilities for heart failure management.
  • The narrative review emphasizes the need for personalized treatments in heart failure focusing on miRNA modulation.

Cite This Study

Micu et al. (2025) studied this question.

synapsesocial.com/papers/68d41ee7713b0b5dfea68398https://doi.org/10.3390/diagnostics15182286
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