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December 23, 2025JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIAOpen Access

Optimization of Self-Nanoemulsifying Drug Delivery System Combining Red Ginger and Aromatic Ginger Extracts to Improve Solubilization and Stability

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Authors

LHLinda HindianaRWRetno WidyowatiSSSukardiman Sukardiman

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Overview

Optimization improves particle size and stability in a self-nanoemulsifying drug delivery system with ginger extracts, indicating better solubilization.

Key Points

  • To optimize a self-nanoemulsifying drug delivery system combining red and aromatic ginger extracts for enhanced solubilization and stability.
  • Varying oil-to-Smix ratio and extract concentration for optimization.
  • Using Virgin coconut oil, Tween 80, and PEG 400 in formulation.
  • Physical characterization involved measuring particle size and polydispersity index before and after stability tests.
  • Formula C showed a 41.5% reduction in droplet size and a 79.9% decrease in PDI compared to Formula B before stability testing.
  • Post-stability testing, Formula C exhibited an 85.5% smaller droplet size and 81.4% lower PDI compared to Formula B.
  • Formula C revealed optimal solubilization capacity and physical stability compared to other formulas.

Cite This Study

Hindiana et al. (2025) studied this question.

synapsesocial.com/papers/6949ddb572f746a93d788f5ehttps://doi.org/10.20473/jfiki.v12i32025.355-363
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