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December 8, 2025Blood

Rethinking disparity in Acute Myeloid Leukemia, a new perspective in the Asian population

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Authors

WXWenbin XiaoESEytan M. Stein

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Overview

Observational analysis revealed racial/ethnic disparities in overall survival for patients with acute myeloid leukemia, highlighting the need for better risk stratification.

Key Points

  • Asian patients with acute myeloid leukemia exhibited significantly longer overall survival compared to White patients, suggesting important disparities.
  • Kaplan-Meier and Cox regression analyses indicated a notable difference in survival rates, with median overall survival of 64.6 months in Asians versus 21.5 months in Whites.
  • The study included comprehensive genomic workup to assess the impact of TP53 alterations on overall survival outcomes in both racial groups.
  • Findings suggest a pressing need for race-inclusive considerations in clinical trials and strategies for managing acute myeloid leukemia disparities.

Cite This Study

Xiao et al. (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e5efhttps://doi.org/10.1182/blood-2025-38
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Racial disparities in genomic alterations and survival outcomes in Acute Myeloid Leukemia (AML)2025
  2. 2Disaggregated outcomes of Asian Americans, Native Hawaiian and Pacific Islander populations with Acute Myeloid Leukemia2025
  3. 3Inferior survival in black AML patients treated with intensive chemotherapy in ECOG-ACRIN clinical trials is independent of cytogenetic profiles2025
  4. 4An analysis of the mutational landscape of Acute Myeloid Leukemia at an urban tertiary care center: A retrospective cohort study2025
  5. 5Real-world post-relapse survival outcomes in children with Acute Myeloid Leukemia by race and ethnicity2025